Response to Comment on Meek et al. Reappearance of C-Peptide During the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care 2021;44:1826–1834

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We read with interest the letter and study synopsis from Ivanisevic and Djelmis (1) and published descriptions (n = ∼30) of their cohort of pregnant women with type 1 diabetes (T1D) (2). It is unclear how many of their participants had detectable C-peptide at baseline. Typically, <50% of women with T1D have detectable C-peptide in early pregnancy, suggesting residual β-cell function (3).
We read with interest the letter and study synopsis from Ivanisevic and Djelmis (1) and published descriptions (n = ∼30) of their cohort of pregnant women with type 1 diabetes (T1D) (2). It is unclear how many of their participants had detectable C-peptide at baseline. Typically, <50% of women with T1D have detectable C-peptide in early pregnancy, suggesting residual β-cell function (3).
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