Response to Comment on Oosterwijk et al. High-Normal Protein Intake Is Not Associated With Faster Renal Function Deterioration in Patients With Type 2 Diabetes: A Prospective Analysis in the DIALECT Cohort. Diabetes Care 2022;45:35–41

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In agreement with expectations expressed in the comment letter by Heyman et al. (1), most of the patients (72%) included in the Diabetes and Lifestyle Cohort Twente used agents that exert renin angiotensin aldosterone system (RAAS) blockade (2). None of the included patients used an inhibitor of sodium–glucose cotransporter 2 (SGLT2). Of note, medication use was assessed at baseline, and there is no information regarding either initiation of an SGLT2 inhibitor or changes in usage and/or dosage of RAAS blockade during follow-up.

In agreement with expectations expressed in the comment letter by Heyman et al. (1), most of the patients (72%) included in the Diabetes and Lifestyle Cohort Twente used agents that exert renin angiotensin aldosterone system (RAAS) blockade (2). None of the included patients used an inhibitor of sodium–glucose cotransporter 2 (SGLT2). Of note, medication use was assessed at baseline, and there is no information regarding either initiation of an SGLT2 inhibitor or changes in usage and/or dosage of RAAS blockade during follow-up.

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